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KMID : 1039420180520040226
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Journal of Pathology and Translational Medicine
2018 Volume.52 No. 4 p.226 ~ p.231
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Hepatocellular Carcinoma Arising in a Huge Hepatocellular Adenoma with Bone Marrow Metaplasia
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Kang Hyo-Jeong
Jeong Hui-Jeong
Kim So-Woon
Yu Eun-Sil
Lee Young-Joo
Kim So-Yeon
Kim Ji-Hun
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Abstract
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Hepatocellular adenoma (HCA) is the most common type of benign liver tumor, and its major complication is malignant transformation to hepatocellular carcinoma (HCC). Here, we report a case of HCC arising in HCA with bone marrow metaplasia in a 24-year-old Korean woman who presented with abdominal discomfort. A huge liver mass was found on abdominal ultrasonography. She underwent surgical hepatic resection, and the resected specimen was entirely involved by a 20-cm-sized tumor. Histological review revealed a well differentiated HCC arising from inflammatory HCA with β-catenin nuclear positivity and bone marrow metaplasia that contained hematopoietic cells. This case was unique because malignant transformation, inflammatory type HCA, β-catenin nuclear staining, and bone marrow metaplasia were simultaneously observed. Additionally, it should be noted that a large HCA with β-catenin activation can undergo malignant transformation and should be surgically resected in a timely manner.
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KEYWORD
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Carcinoma, hepatocellular, Adenoma, liver cell, Bone marrow metaplasia, β-catenin
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